Joseph N. Benoit, Ph.D.
Assistant Dean for Research
Professor of Physiology & Pathology

Room 309
Phone: 575- 674-2321
Departments: Office of Research & Sponsored Programs.
Physiology & Pathology

Joseph N. Benoit, Ph.D. is Assistant Dean for Research and Professor of Physiology & Pathology. His career as an academic spans more than thirty-years, and has involved working at all levels ranging from the professoriate where he has held faculty appointments at five medical schools to graduate school dean with campus wide authority to president of a Benedictine liberal arts college. His early research centered on microvascular physiology, vascular smooth muscle regulation and lymphatic physiology. In recent years, he has devoted his efforts to new and emerging medical schools where his work involves curriculum design, building research infrastructure, faculty development, and teaching. Dr. Benoit has published more that 200 papers, abstracts and book chapters. He has been invited to speak on his scholarly work in the U.S., Canada, Japan, China, Europe, and Australia.


Doctor of Philosophy (Ph.D.), Basic Medical Science
University of South Alabama, Mobile, Alabama

Bachelor of Science (B.S.), Basic Medical Science
University of South Alabama, Mobile, Alabama

Bachelor of Science (B.S.), Biology & Chemistry
University of Southwestern Louisiana, Lafayette, Louisiana

Postdoctoral Fellowship:
Texas A&M University

Research Interests

  • Cardiovascular Complications of Portal Hypertension
  • Regulation of Vascular Smooth Muscle Contraction in Health & Disease
  • Lymphatic Physiology
  • Mathematical Modeling of Physiological Systems
  • Curriculum Design & Assessment
  • Research Ethics and Regulatory Compliance

Professional Accomplishments & Memberships

Professional Affiliations:
American Physiological Society
Rockville, MD

AAALAC, International
Frederick, MD

National Council of University Research Administrators
Washington, D.C.

Public Responsibility in Medicine & Research
Boston, MA

Community Affiliations:
Mesilla Valley Concert Band
Las Cruces, NM

New Horizons Symphony at New Mexico State University
Las Cruces, NM

Astronomical Society of Las Cruces
Las Cruces, NM

New Horizons Band at New Mexico State University
Las Cruces, NM

Selected Publications

Benoit JN, Weichbrod RH, Norton JN, Garber JC. Future Directions and Challenges. In: Weichbrod RH, Thompson GAH, Norton JN, editors. Management of Animal Care and Use Programs in Research, Education, and Testing. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 36. PubMed PMID: 29787212.

Anderson CM, Lopez F, Zhang HY, Shirasawa Y, Pavlish K, Benoit JN. Mesenteric vascular responsiveness in a rat model of pregnancy-induced hypertension. Exp Biol Med (Maywood). 2006 Sep;231(8):1398-402. PubMed PMID: 16946408.

Chen X, Pavlish K, Benoit JN. Myosin phosphorylation triggers actin polymerization in vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2172-7. doi: 10.1152/ajpheart.91437.2007. Epub 2008 Oct 3. PubMed PMID: 18835913; PubMed Central PMCID: PMC2614591.

Chen X, Pavlish K, Zhang HY, Benoit JN. Effects of chronic portal hypertension on agonist-induced actin polymerization in small mesenteric arteries. Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1915-21. Epub 2005 Dec 9. PubMed PMID: 16339838.

Anderson CM, Lopez F, Zimmer A, Benoit JN. Placental insufficiency leads to developmental hypertension and mesenteric artery dysfunction in two generations of Sprague-Dawley rat offspring. Biol Reprod. 2006 Mar;74(3):538-44. Epub 2005 Nov 23. PubMed PMID: 16306423.

Anderson CM, Lopez F, Zhang HY, Pavlish K, Benoit JN. Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia. Am J Obstet Gynecol. 2005 Jul;193(1):267-72. PubMed PMID: 16021089.

Benoit JN, Bayne K. Training the trainee: the institution’s responsibility to the often forgotten. Lab Anim (NY). 2005 Jun;34(6):46-50. PubMed PMID: 15924132.

Anderson CM, Lopez F, Zhang HY, Pavlish K, Benoit JN. Reduced uteroplacentalperfusion alters uterine arcuate artery function in the pregnant Sprague-Dawley rat. Biol Reprod. 2005 Mar;72(3):762-6. Epub 2004 Nov 24. PubMed PMID: 15564595.

Zhang HY, Shirasawa Y, Chen X, Yu H, Benoit JN. Impaired agonist-dependent myosin phosphorylation and decreased RhoA in rat portal hypertensive mesenteric vasculature. Am J Physiol Gastrointest Liver Physiol. 2005 Apr;288(4):G603-8. Epub 2004 Oct 28. PubMed PMID: 15513955.

Chen X, Zhang HY, Pavlish K, Benoit JN. Effects of chronic portalhypertension on small heat-shock proteins in mesenteric arteries. Am J Physiol Gastrointest Liver Physiol. 2005 Apr;288(4):G616-20. Epub 2004 Oct 28. PubMed PMID: 15513950.

Shirasawa Y, Benoit JN. Stretch-induced calcium sensitization of rat lymphatic smooth muscle. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2573-7. Epub 2003 Aug 28. PubMed PMID: 12946938.

Young JL, Benoit JN, Dean DA. Effect of a DNA nuclear targeting sequence ongene transfer and expression of plasmids in the intact vasculature. Gene Ther. 2003 Aug;10(17):1465-70. PubMed PMID: 12900761; PubMed Central PMCID: PMC4150867.

Krenz M, Oldenburg O, Wimpee H, Cohen MV, Garlid KD, Critz SD, Downey JM, Benoit JN. Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res Cardiol. 2002 Sep;97(5):365-73. PubMed PMID: 12200636.

Oldenburg O, Qin Q, Sharma AR, Cohen MV, Downey JM, Benoit JN. Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase. Cardiovasc Res. 2002 Aug 15;55(3):544-52. PubMed PMID: 12160951.

Martin JB, Young JL, Benoit JN, Dean DA. Gene transfer to intact mesenteric arteries by electroporation. J Vasc Res. 2000 Sep-Oct;37(5):372-80. PubMed PMID: 11025400; PubMed Central PMCID: PMC4152911.

Gardner JD, Benoit JN. Effects of capacitative calcium entry on agonist-induced calcium transients in A7r5 vascular smooth muscle cells. J Biomed Sci. 2000 Jul-Aug;7(4):304-10. PubMed PMID: 10895053.

Taylor MS, Benoit JN. Effect of milrinone on small mesenteric artery vasoconstriction: role of K(+) channels. Am J Physiol. 1999 Jul;277(1):G69-78. doi: 10.1152/ajpgi.1999.277.1.G69. PubMed PMID: 10409153.

Taylor MS, Gao H, Gardner JD, Benoit JN. Effects of IBMX on norepinephrine-induced vasoconstriction in small mesenteric arteries. Am J Physiol. 1999 Apr;276(4):G909-14. doi: 10.1152/ajpgi.1999.276.4.G909. PubMed PMID: 10198334.

Benoit JN. Effects of alpha-adrenergic stimuli on mesenteric collecting lymphatics in the rat. Am J Physiol. 1997 Jul;273(1 Pt 2):R331-6. PubMed PMID:9249568.

Wu ZY, Benoit JN. Altered vascular norepinephrine responses in portal hypertensive intestine: role of PKA and guanylate cyclase. Am J Physiol. 1997 Apr;272(4 Pt 1):G831-7. PubMed PMID: 9142915.

Gao H, Korthuis RJ, Benoit JN. Hypoxia/reoxygenation selectively impairs alpha 1b-adrenoceptor function in small mesenteric arteries. Am J Physiol. 1996 Nov;271(5 Pt 1):G820-3. PubMed PMID: 8944696.

Yokoyama S, Benoit JN. Effects of bradykinin on lymphatic pumping in rat mesentery. Am J Physiol. 1996 May;270(5 Pt 1):G752-6. PubMed PMID: 8967485.

Yokoyama S, Korthuis RJ, Benoit JN. Hypoxia-reoxygenation impairs endothelium-dependent relaxation in isolated rat aorta. Am J Physiol. 1996 May;270(5 Pt 2):R1126-31. PubMed PMID: 8928916.

Gao H, Korthuis RJ, Benoit JN. Effects of hypoxia/reoxygenation on aortic vasoconstrictor responsiveness. Free Radic Biol Med. 1996;21(5):591-600. PubMed PMID: 8891662.

Wu ZY, Benoit JN. Effects of propranolol on intestinal microcirculation of normal and portal hypertensive rats. J Hepatol. 1995 Jun;22(6):677-84. PubMed PMID: 7560861.

Wu ZY, Benoit JN. Nonreceptor-mediated intestinal vasoconstriction in portal hypertensive rats. Am J Physiol. 1994 Jul;267(1 Pt 2):H370-5. PubMed PMID: 8048603.

Gao H, Korthuis RJ, Benoit JN. Effects of reactive oxygen metabolites on norepinephrine-induced vasoconstriction. Free Radic Biol Med. 1994 Jun;16(6):839-43. PubMed PMID: 8070689.

Wu ZY, Benoit JN. Vascular NE responsiveness in portal hypertension: role of portal pressure and portosystemic shunting. Am J Physiol. 1994 Mar;266(3 Pt 2):H1162-8. PubMed PMID: 8160819.

Joh T, Granger DN, Benoit JN. Endogenous vasoconstrictor tone in intestine of normal and portal hypertensive rats. Am J Physiol. 1993 Jan;264(1 Pt 2):H171-7. PubMed PMID: 8430843.

Benoit JN, Zawieja DC. Effects of f-Met-Leu-Phe-induced inflammation on intestinal lymph flow and lymphatic pump behavior. Am J Physiol. 1992 Feb;262(2 Pt 1):G199-202. PubMed PMID: 1539654.

Benoit JN. Relationships between lymphatic pump flow and total lymph flow in the small intestine. Am J Physiol. 1991 Dec;261(6 Pt 2):H1970-8. PubMed PMID: 1750545.

Thomas SH, Joh T, Benoit JN. Role of bile acids in splanchnic hemodynamic response to chronic portal hypertension. Dig Dis Sci. 1991 Sep;36(9):1243-8. PubMed PMID: 1893807.

Joh T, Granger DN, Benoit JN. Intestinal microvascular responsiveness to norepinephrine in chronic portal hypertension. Am J Physiol. 1991 Apr;260(4 Pt 2):H1135-43. PubMed PMID: 2012219.

Mesh CL, Joh T, Korthuis RJ, Granger DN, Benoit JN. Intestinal vascular sensitivity to vasopressin in portal hypertensive rats. Gastroenterology. 1991 Apr;100(4):916-21. PubMed PMID: 2001829.

Grisham MB, Benoit JN, Granger DN. Assessment of leukocyte involvement during ischemia and reperfusion of intestine. Methods Enzymol. 1990;186:729-42. PubMed PMID: 2172726.

Benoit JN, Zawieja DC, Goodman AH, Granger HJ. Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress. Am J Physiol. 1989 Dec;257(6 Pt 2):H2059-69. PubMed PMID: 2603989.

Benoit JN, Granger DN. Intestinal microvascular adaptation to chronic portal hypertension in the rat. Gastroenterology. 1988 Feb;94(2):471-6. PubMed PMID: 3335318.

Benoit JN, Zimmerman B, Premen AJ, Go VL, Granger DN. Role of glucagon in splanchnic hyperemia of chronic portal hypertension. Am J Physiol. 1986 Nov;251(5 Pt 1):G674-7. PubMed PMID: 3777172.

Benoit JN, Womack WA, Korthuis RJ, Wilborn WH, Granger DN. Chronic portal hypertension: effects on gastrointestinal blood flow distribution. Am J Physiol. 1986 Apr;250(4 Pt 1):G535-9. PubMed PMID: 3963197.

Benoit JN, Womack WA, Hernandez L, Granger DN. “Forward” and “backward” flow mechanisms of portal hypertension. Relative contributions in the rat model of portal vein stenosis. Gastroenterology. 1985 Nov;89(5):1092-6. PubMed PMID:4043666.

Kiel JW, Pitts V, Benoit JN, Granger DN, Shepherd AP. Reduced vascular sensitivity to norepinephrine in portal-hypertensive rats. Am J Physiol. 1985 Feb;248(2 Pt 1):G192-5. PubMed PMID: 3970200.

Benoit JN, Barrowman JA, Harper SL, Kvietys PR, Granger DN. Role of humoral factors in the intestinal hyperemia associated with chronic portal hypertension. Am J Physiol. 1984 Nov;247(5 Pt 1):G486-93. PubMed PMID: 6496739.

Anzueto L, Benoit JN, Granger DN. A rat model for studying the intestinal circulation. Am J Physiol. 1984 Jan;246(1 Pt 1):G56-61. PubMed PMID: 6696068.

Perry MA, Benoit JN, Kvietys PR, Granger DN. Restricted transport of cationic macromolecules across intestinal capillaries. Am J Physiol. 1983 Oct;245(4):G568-72. PubMed PMID: 6194696.